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  1. Rhodopsin (RHO) is the most well-known genetic cause of autosomal dominant retinitis pigmentosa (adRP). This study aimed to investigate the genetic cause of a large Chinese adRP family and assess the pathogeni...

    Authors: Yue Wang, Xi Chen, Xiang Gao, Andi Zhao, Chen Zhao and Xuejuan Chen

    Citation: BMC Ophthalmology 2021 21:371

    Content type: Research

    Published on:

  3. The pathogenesis of myopia has been found to be associated with the blood supply of the choroid. This study aimed to determine the relationship between the distribution pattern of choroidal remodeling and the ...

    Authors: Jun Wang, Xin Ye, Xiangjun She, Jiahao Xu, Yiqi Chen, Jiwei Tao, Xinjie Ye and Lijun Shen

    Citation: BMC Ophthalmology 2021 21:369

    Content type: Research

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  4. We report a case of Corynebacterium endophthalmitis secondary to tube exposure following Baerveldt glaucoma implant surgery that was successfully treated with prompt tube withdrawal and temporary subconjunctival ...

    Authors: Naruka Mitsui, Kae Sugihara, Jiro Seguchi, Etsuo Chihara, Yuki Morizane and Akiko Narita

    Citation: BMC Ophthalmology 2021 21:368

    Content type: Case report

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  5. Capsule contraction syndrome (CCS) after cataract surgery causes intraocular lens (IOL) haptic flexion and IOL optic displacement in most former reports. However, there are few reports on CCS-induced deformati...

    Authors: Wei Wang, Dejian Xu, Xin Liu and Wen Xu

    Citation: BMC Ophthalmology 2021 21:367

    Content type: Case report

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  6. Achieving an appropriate vault is the main concern after the implantation of Implantable Collamer Lens (ICLs) for surgical correction of high myopia. The vault will vary with time and optical parameters, such ...

    Authors: Ying Xiong, Yingyan Mao, Jing Li, Xiuhua Wan, Meng Li, Jingshang Zhang, Jinda Wang and Xiuli Sun

    Citation: BMC Ophthalmology 2021 21:366

    Content type: Research

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  7. To compare clinical outcomes and optical performance of a new monofocal with enhanced intermediate function intraocular lenses (IOLs) with that of conventional monofocal IOLs.

    Authors: Jungah Huh, Youngsub Eom, Seul Ki Yang, Young Choi, Hyo Myung Kim and Jong Suk Song

    Citation: BMC Ophthalmology 2021 21:365

    Content type: Research

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  9. Early and effective ocular screening may help to eliminate treatable eye disorders. The Lhasa Childhood Eye Study (LCES) revealed the particular prevalence of refractive error and visual impairment in grade on...

    Authors: Jiantao Cui, Jing Fu, Lei Li, Weiwei Chen, Zhaojun Meng, Han Su, Yao Yao and Wei Dai

    Citation: BMC Ophthalmology 2021 21:363

    Content type: Research

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  10. To investigate whether the treatment zone size (TZS) and treatment zone decentration (TZD) will affect the axial elongation in myopic children undergoing orthokeratology treatment.

    Authors: Weiping Lin, Na Li, Tianpu Gu, Chunyu Tang, Guihua Liu, Bei Du and Ruihua Wei

    Citation: BMC Ophthalmology 2021 21:362

    Content type: Research article

    Published on:

  11. To investigate the incidence of absent Bell’s phenomenon (BP) and the relationship between absent BP and inferior rectus muscle hypertrophy and other clinical features in patients with thyroid eye disease (TED).

    Authors: Hyun Woo Chung, Hwa Lee and Sehyun Baek

    Citation: BMC Ophthalmology 2021 21:361

    Content type: Research article

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  14. To investigate the clinical characteristics of children with congenital ptosis, with particular attention given to the incidence of anisometropia, and the difference in axial length (AL) between the right and ...

    Authors: Satoshi Ueki, Yuji Suzuki, Megumi Kiyokawa, Takako Hanyu and Takeo Fukuchi

    Citation: BMC Ophthalmology 2021 21:358

    Content type: Research

    Published on:

  15. Keratoconus is a chronic degenerative disorder of the cornea characterized by thinning and cone-shaped protrusions. Although genetic factors play a key role in keratoconus development, the etiology is still un...

    Authors: Liubov O. Skorodumova, Alexandra V. Belodedova, Elena I. Sharova, Elena S. Zakharova, Liliia N. Iulmetova, Mukharram M. Bikbov, Emin L. Usubov, Olga P. Antonova, Oksana V. Selezneva, Anastasia Levchenko, Olga Yu Fedorenko, Svetlana A. Ivanova, Raul R. Gainetdinov and Boris E. Malyugin

    Citation: BMC Ophthalmology 2021 21:357

    Content type: Research

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  16. To identify the prevalence of positive IgG4 immunostaining in orbital tissue among patients previously diagnosed with nongranulomatous idiopathic orbital inflammation (IOI) and to compare the clinical characte...

    Authors: Orapan Aryasit, Nanida Tiraset, Passorn Preechawai, Kanita Kayasut, Nuttha Sanghan and Wantanee Sittivarakul

    Citation: BMC Ophthalmology 2021 21:356

    Content type: Research

    Published on:

  17. Kikuchi-Fujimoto disease (KFD) is a necrotizing lymphadenitis, and presents fever of unknown origin and cervical lymphadenopathy. Ocular complications are unusual in KFD. Here we report a case of sub internal ...

    Authors: Tomohito Sato, Koji Kanda, Yusuke Kawamura and Masaru Takeuchi

    Citation: BMC Ophthalmology 2021 21:355

    Content type: Case report

    Published on:

  18. The purpose of this cross-sectional study involving healthy emmetropic four-year-old Caucasian children was to provide a macular perfusion normative database acquired with optical coherence tomography angiogra...

    Authors: Dunja Bajtl, Mirjana Bjeloš, Mladen Bušić, Ana Križanović, Leon Marković and Biljana Kuzmanović Elabjer

    Citation: BMC Ophthalmology 2021 21:354

    Content type: Research

    Published on:

  20. Susac syndrome (SS) is characterized by the triad of encephalopathy, branch retinal artery occlusion, and sensorineural hearing loss. However, the diagnosis of SS remains difficult because the clinical triad r...

    Authors: Joanna Roskal-Wałek, Michał Biskup, Magdalena Dolecka-Ślusarczyk, Anita Rosołowska, Andrzej Jaroszyński and Dominik Odrobina

    Citation: BMC Ophthalmology 2021 21:352

    Content type: Case report

    Published on:

  23. The effect of diabetic retinopathy (DR) on the development of sight-threatening cataracts was assessed using the National Health Insurance Research Database of Taiwan.

    Authors: Chan-Wei Nien, Chia-Yi Lee, Hung-Chi Chen, Shih-Chun Chao, Hung-Jui Hsu, Shih-Hao Tzeng, Shang-Jung Yang, Jing-Yang Huang, Shun-Fa Yang and Hung-Yu Lin

    Citation: BMC Ophthalmology 2021 21:349

    Content type: Research

    Published on:

  24. We conducted the study to compare the psychometric properties of the English version of the Questionnaire and the Bahasa Malaysia (Malay Language) version regarding the vision-related Quality of Life of patien...

    Authors: Thanigasalam Thevi, Adinegara Lutfi Abas and Chang Stephanie Yen Li

    Citation: BMC Ophthalmology 2021 21:348

    Content type: Research article

    Published on:

  26. In response to the COVID-19 pandemic, a web-based tele-triage system was created to prioritize in-person clinic visits and ensure safety at the University of Illinois at Chicago Department of Ophthalmology and...

    Authors: Angelica C. Scanzera, Arthur Y. Chang, Nita Valikodath, Emily Cole, Joelle A. Hallak, Thasarat Sutabutr Vajaranant, Sage J. Kim and R. V. Paul Chan

    Citation: BMC Ophthalmology 2021 21:346

    Content type: Research

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  31. The purpose of this study was to implement and evaluate a deep learning (DL) approach for automatically detecting shallow anterior chamber depth (ACD) from two-dimensional (2D) overview anterior segment photog...

    Authors: Zhuyun Qian, Xiaoling Xie, Jianlong Yang, Hongfei Ye, Zhilei Wang, Jili Chen, Hui Liu, Jianheng Liang, Lihong Jiang, Ce Zheng and Xu Chen

    Citation: BMC Ophthalmology 2021 21:341

    Content type: Research

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  32. Anterior segment surgeries such as cataract surgery, intraocular lens (IOL) repositioning, and radial keratotomy (RK) may hasten endothelial dysfunction, particularly in the context of pre-existing Fuchs dystr...

    Authors: Anvesh Annadanam, Timothy Soeken, Manjool Shah and Nambi Nallasamy

    Citation: BMC Ophthalmology 2021 21:340

    Content type: Case report

    Published on:

  33. In vivo corneal biomechanics evaluation has been used to help screen early keratoconus in recent years. This study is to evaluate the value of a Scheimpflug-based biomechanical analyser combined with tomograph...

    Authors: Yan Liu, Yu Zhang and Yueguo Chen

    Citation: BMC Ophthalmology 2021 21:339

    Content type: Research article

    Published on:

  34. Imaging mass cytometry (IMC) combines the principles of flow cytometry and mass spectrometry (MS) with laser scanning spatial resolution and offers unique advantages for the analysis of tissue samples in unpre...

    Authors: Anja Schlecht, Stefaniya Boneva, Henrike Salie, Saskia Killmer, Julian Wolf, Rozina Ida Hajdu, Claudia Auw-Haedrich, Hansjürgen Agostini, Thomas Reinhard, Günther Schlunck, Bertram Bengsch and Clemens AK Lange

    Citation: BMC Ophthalmology 2021 21:338

    Content type: Technical advance

    Published on:

  35. Acute retinal necrosis is considered a rare infectious uveitis. This condition is usually caused by varicella-zoster virus or herpes simplex virus. Acute retinal necrosis caused by co-infection with multiple v...

    Authors: Kasra Cheraqpour, Aliasghar Ahmadraji, Ali Rashidinia, Maziyar Irannejad and Mansoor Shahriari

    Citation: BMC Ophthalmology 2021 21:337

    Content type: Case report

    Published on:

  36. There are few reports regarding the influence of varying illumination on the compensation effect before and after corneal refractive surgery. We aimed to evaluate the changes in refraction, higher-order aberra...

    Authors: Weiting Hao, Yan Wang, Tong Cui, Wenxing Ning, Qing Zhu and Yaohua Zhang

    Citation: BMC Ophthalmology 2021 21:336

    Content type: Research

    Published on:

  37. Leukemic involvement of the eyes is rare, therefore, treatment relies on previous case reports. The treatment of ocular complications poses additional difficulties, because the eye is considered as a pharmacol...

    Authors: Douglas Rodrigues da Costa, Rodrigo Dahia Fernandes, Fernanda Nicolela Susanna, Epitácio Dias da Silva Neto and Mario Luiz Ribeiro Monteiro

    Citation: BMC Ophthalmology 2021 21:335

    Content type: Case report

    Published on:

  38. To evaluate the relevance of external limiting membrane (ELM) on the visual and morphological results in eyes with diabetic macular edema (DME) that underwent pars plana vitrectomy (PPV) with epiretinal membra...

    Authors: Domagoj Ivastinovic, Anton Haas, Martin Weger, Gerald Seidel, Christoph Mayer-Xanthaki, Ewald Lindner, Andreas Guttmann and Andreas Wedrich

    Citation: BMC Ophthalmology 2021 21:334

    Content type: Research article

    Published on:

  39. Plasma medicine is an innovative research field focused on the application of atmospheric-pressure low-temperature plasmas (ALTP) for therapeutic purposes. Considering the potentials of plasma in ophthalmology...

    Authors: Farhad Nejat, Khosrow Jadidi, Fahimeh Asadi Amoli, Shiva Bagheri, Hossein Aghamollaei, Mohammad-Amin Nejat, Nazanin-Sadat Nabavi and Shima Eghtedari

    Citation: BMC Ophthalmology 2021 21:333

    Content type: Research

    Published on:

  40. The present study sought to observe the effect of retaining intact posterior capsule in congenital cataract surgery in children aged 4–8 years.

    Authors: Jing Shang Zhang, Jin Da Wang, Mayinuer Yusufu, Kai Cao, Shan Shan Jin, Ying Xiong, Jing Li, Xiu Li Sun, Shu Ying Chen, Zhen Yu Liu, Jing Fu, Li Li, Qi Sheng You and Xiu Hua Wan

    Citation: BMC Ophthalmology 2021 21:332

    Content type: Research

    Published on:

  41. To evaluate macular microstructure alterations in the parafoveal nonperfusion areas of eyes with branch retinal vein occlusions (BRVO), and to investigate their impact on retinal sensitivity.

    Authors: Puying Wei, Chenchen Liu, Yanzhen Zhang and Liu Yang

    Citation: BMC Ophthalmology 2021 21:331

    Content type: Research

    Published on:

  42. To assess the effects of warm compress (WC) on tear film lipid layer, blink pattern and Meibomian gland function in patients with dry eye following femtosecond laser small incision lenticule extraction (SMILE)...

    Authors: Xueyi Zhou, Yang Shen, Jianmin Shang and Xingtao Zhou

    Citation: BMC Ophthalmology 2021 21:330

    Content type: Research

    Published on:

  43. To investigate the effects of small incision lenticule extraction (SMILE)-derived decellularized lenticules on intraocular pressure (IOP) and conjunctival scarring in a rabbit model of glaucoma filtration surg...

    Authors: Houfa Yin, Xinyi Chen, Xiaogang Hong, Jian Ma, Fang Wu, Ting Wan, Yiwen Sang, Qiuli Fu, Zhenwei Qin, Danni Lyu, Wei Wu, Jinfu Yin and Yabo Yang

    Citation: BMC Ophthalmology 2021 21:329

    Content type: Research

    Published on:

  44. The purpose of this study was to investigate diagnostic ability of peripapillary vessel density of primary angle closure glaucoma (PACG) eyes in quadrant and clock-hour sectors by optical coherence tomography ...

    Authors: Yongdong Lin, Shirong Chen and Mingzhi Zhang

    Citation: BMC Ophthalmology 2021 21:328

    Content type: Research

    Published on:

  45. Neurotrophic keratopathy (NK) is a relatively uncommon, underdiagnosed degenerative corneal disease that is caused by damage to the ophthalmic branch of the trigeminal nerve by conditions such as herpes simple...

    Authors: Reza Dana, Marjan Farid, Preeya K. Gupta, Pedram Hamrah, Paul Karpecki, Cathleen M. McCabe, Lisa Nijm, Jay S. Pepose, Stephen Pflugfelder, Christopher J. Rapuano, Arvind Saini, Sarah N. Gibbs and Michael S. Broder

    Citation: BMC Ophthalmology 2021 21:327

    Content type: Research

    Published on:

  46. Highly myopic eyes differ in morphology from emmetropic eyes, and the correct estimation of the vitreous volume is difficult. To explore an effective method to estimate ocular volume using refractive factors i...

    Authors: Xiaodan Jiang, Hongwei Deng, Chun Lung, Fanyin Wang, Shuang Li, Yanni Jiang and Mingyue Wang

    Citation: BMC Ophthalmology 2021 21:326

    Content type: Research

    Published on:

  47. Designing educational interventions tailored to the needs of Contact Lens Wearers (CLWs) are important and necessary. The present study aimed to determine the information needs of CLWs to educate and provide i...

    Authors: Fatemeh Falahati-Marvast, Fateme Alipour, Jamileh Farokhzadian and Leila Ahmadian

    Citation: BMC Ophthalmology 2021 21:325

    Content type: Research

    Published on:

  48. Ocular parasitosis can cause eye damage, which contribute to eye symptoms such as burning, itching and even blindness. It is uncommon to see the parasitosis lying in the sclera layer, neither it causing pteryg...

    Authors: Wenjie Zeng, Zhaoyi Pan, Jun Wang, Xianghui Deng and Wenmin Jiang

    Citation: BMC Ophthalmology 2021 21:323

    Content type: Case report

    Published on:

  49. Full-thickness macular hole (FTMH) is a rare complication in retinitis pigmentosa (RP) patients and may increase intraoperative challenges. Furthermore, lens capsular flap transplantation and inverted internal...

    Authors: Chia-Ying Lee, Chung-May Yang, Chang-Hao Yang, Fung-Rong Hu and Ta-Ching Chen

    Citation: BMC Ophthalmology 2021 21:322

    Content type: Case report

    Published on:

  50. Regular membrane peeling vitrectomy for epiretinal membrane (ERM) patients seldom causes large pigment epithelial detachment (PED). We presented an unusual case of the activation of quiescent polypoidal choroi...

    Authors: Yuelin Wang, Zhe Chen, Weihong Yu and Youxin Chen

    Citation: BMC Ophthalmology 2021 21:321

    Content type: Case report

    Published on:

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